Proton Pump Inhibitors and C. difficile Infection: A Perspective
نویسندگان
چکیده
In the last two decades, epidemiological data from United States national administrative databases and population-based studies have shown a two to six-fold increase in the incidence of Clostridium difficile infection (CDI), especially in the elderly [1-3]. This increase has been observed in diverse settings with C. difficile replacing methicillin resistant Staphylococcus aureus (MRSA) as the most common nosocomial infection in parts of the U. S, [4] and being increasingly recognized as a cause of diarrhea in the community [5].
منابع مشابه
Overuse and inappropriate prescribing of proton pump inhibitors in patients with Clostridium difficile-associated disease.
BACKGROUND Clostridium difficile is the most common infectious cause of colitis and has been increasingly diagnosed in hospitalized patients. The number of prescriptions for proton pump inhibitors (PPIs) has also increased significantly over time. Few studies have reported an association between C. difficile-associated disease (CDAD) and PPI use. AIM To assess the extent and appropriateness o...
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Children with cystic fibrosis (CF) often take proton pump inhibitors (PPIs), which helps improve efficacy of fat absorption with pancreatic enzyme replacement therapy. However, PPI use is known to be associated with Clostridium difficile-(C. diff-) associated diarrhea (CDAD). We retrospectively evaluated the incidence of C. diff infection from all pediatric hospital admissions over a 5-year per...
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